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NMR determination of the enantiomer composition of penicillamine using an optically active europium shift reagent

✍ Scribed by Anthony F. Cockerill; Geoffrey L. O. Davies; Roger G. Harrison; David M. Rackham

Publisher: John Wiley and Sons
Year: 1974
Tongue: English
Weight: 175 KB
Volume: 6
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1270061214

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✦ Synopsis

Abstract

An NMR method is described for assaying the enantiomer composition of the pharmacologically active material penicillamine (1), using tris‐(3‐heptafluorobutyryl‐d‐camphorato)europium. The L enantiomer can be detected at levels of 0·4 to 0·5% in DL mixtures. Problems due to the insolubility of penicillamine in nonpolar solvents can be overcome by a two step derivatisation procedure.

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