NMR compartmentalization of free water in the perfused rat heart

✍ Scribed by Y. Mauss; D. Grucker; D. Fornasiero; J. Chambron

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 426 KB
• Volume: 2
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910020302

✦ Synopsis

Spin-lattice (TI) and spin-spin ( T2) relaxation times have been measured on perfused rat hearts under two experimental conditions. TI exhibits a monoexponential decay. On the other hand Tz has a decay with two components: a short one T,, and a long one T2,. These facts have been discussed according to cross-relaxation and a bicompartmentalization of tissue assuming a slow exchange model for spin-spin relaxation and a fast exchange model for spin-lattice relaxation. Increasing the osmotic pressure of the perfusion solution decreased the absolute density proton of the Tz, compartment reflecting the loss of its water content. The paramagnetic ion manganese diminishes the values of TI and those of the long component TZI without affecting its short component. Therefore the short component could be assigned to intracellular and the long component to extracellular free water. The extracellular T2 (459 ms) is approximatively 10-fold higher than the intracellular Tz (45 ms). With images of "pure Ti' such a difference could be useful to enhance the contrast between organs and the surrounding liquid or between organs with different water compartmentalization. 0 1985 Academic Press, Inc.