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NMR characterization of the full-length recombinant murine prion protein, mPrP(23–231)

✍ Scribed by Roland Riek; Simone Hornemann; Gerhard Wider; Rudi Glockshuber; Kurt Wüthrich


Book ID
117108021
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
598 KB
Volume
413
Category
Article
ISSN
0014-5793

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✍ Luisa Ronga; Pasquale Palladino; Gabriella Saviano; Teodorico Tancredi; Ettore B 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 192 KB

## Abstract The 173–195 segment corresponding to the helix 2 of the globular PrP domain is a good candidate to be one of the several ‘spots’ of intrinsic structural flexibility, which might induce local destabilization and concur to protein transformation, leading to aggregation‐prone conformations