NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing
β Scribed by Zhoumou Chen; Carolina Muscoli; Tim Doyle; L. Bryant; Salvatore Cuzzocrea; Vincenzo Mollace; Rosanna Mastroianni; Emanuela Masini; Daniela Salvemini
- Book ID
- 113839212
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 408 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0304-3959
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The linkage of the N-methyl-D-aspartate (NMDA) subtype of L-glutamate receptor to the nitric oxide (N0)/3',S'-cyclic guanosine monophosphate (cGMP) intracellular signalling system was investigated in murine neocortical cultures by examining the effects of NMDA antagonists, NO synthase inhibitors, an
## Abstract Chemical transmitters released from astrocytes, termed gliotransmitters, modulate synaptic transmission and neuronal function. Using astrocyteβspecific inducible transgenic mice (dnSNARE mice), we have demonstrated that inhibiting gliotransmission leads to reduced activation of adenosin