Activation of NMDA Receptor is Associated with Up-regulation of COX-2 Expression in the Spinal Dorsal Horn during Nociceptive Inputs in Rats

Phosphorylation of ERK in the spinal dor

Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase-activated receptor-2 agonists and hydrogen sulfide in rats: Evidence for involvement of distinct mechanisms

✍ Osamu Fukushima; Sachiyo Nishimura; Maho Matsunami; Yuka Aoki; Hiroyuki Nishikaw 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 866 KB

## Abstract Noxious stimuli cause prompt phosphorylation of extracellular signal‐regulated kinase (ERK) in the spinal dorsal horn that contributes to facilitation of pain sensation and is often used as an immediate marker for excitation of spinal neurons following somatic and colonic nociception. H