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NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia

✍ Scribed by Moussa, Heba; Sidhom, Iman


Book ID
127178817
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
189 KB
Volume
12
Category
Article
ISSN
1743-7555

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Cytogenetic analysis of a pediatric T-cell acute lymphoblastic leukemia (ALL) cell line (HPB-ALL) revealed the cryptic t(5;14)(q35;q32.2), recently found in 15-20% pediatric T-ALL patients, with 5q35 and 14q32.2 breakpoints at 5'-HOX11L2 and 3'-BCL11B, respectively. Expression of both BCL11B, which