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NK2 antagonists and the role of NK2 receptors

โœ Scribed by R.M. Hagan; I.J.M. Beresford; P.J. Elliott; D.I. Ball; R.L.G. Sheldrick; S.J. Ireland; J.M. Pritchard; A.B. McElroy; P. Ward


Book ID
119117584
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
69 KB
Volume
37
Category
Article
ISSN
0167-0115

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The conformational space of two NK2 receptor agonists and a new potent antagonist has been sampled by the simulated annealing technique. Low-energy conformers were obtained, which were compared with respect to their key residues, namely phenylalanine, leueine and methionine. The hypothesis is that t