Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists
β Scribed by R.M. Hagan; I.J.M. Beresford; J. Stables; J. Dupere; C.M. Stubbs; P.J. Elliott; R.L.G. Sheldrick; A. Chollet; E. Kawashima; A.B. McElroy; P. Ward
- Book ID
- 119117770
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 668 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0167-0115
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π SIMILAR VOLUMES
The conformational space of two NK2 receptor agonists and a new potent antagonist has been sampled by the simulated annealing technique. Low-energy conformers were obtained, which were compared with respect to their key residues, namely phenylalanine, leueine and methionine. The hypothesis is that t
## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)βNβ[3,4βdichlorobenzyl)]β4β[(hexahydroβ2βoxoβ1Hβazepinβ3βyl)amino]βNβmethylβ3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high