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Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists

✍ Scribed by R.M. Hagan; I.J.M. Beresford; J. Stables; J. Dupere; C.M. Stubbs; P.J. Elliott; R.L.G. Sheldrick; A. Chollet; E. Kawashima; A.B. McElroy; P. Ward


Book ID
119117770
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
668 KB
Volume
46
Category
Article
ISSN
0167-0115

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high