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Nitrosylation of Sickle Cell Hemoglobin by Hydroxyurea

โœ Scribed by Xu, Yueping; Mull, Courtney D.; Bonifant, Challice L.; Yasaki, Genichiro; Palmer, Eric C.; Shields, Howard; Ballas, Samir K.; Kim-Shapiro, Daniel B.; King, S. Bruce


Book ID
120159922
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
74 KB
Volume
63
Category
Article
ISSN
0022-3263

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Hydroxyurea-induced denaturation of norm
โœ D. Roa; P. Kopsombut; M. d. P. Aguinaga; E. A. Turner ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 104 KB ๐Ÿ‘ 2 views

Use of hydroxyurea (HU) to treat sickle cell disease is usually associated with increments in fetal hemoglobin (Hb F) production; however, in vitro studies show that HU may also induce hemoglobin denaturation. Whole blood samples from Hb AA, Hb AS, and Hb SS patients were treated in vitro with 100,