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Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat

✍ Scribed by S. Fredduzzi; G. Mariucci; M. Tantucci; P. Del Soldato; M.V. Ambrosini

Book ID: 117471611
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 252 KB
Volume: 302
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(01)01672-x

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## Abstract The proinflammatory cytokine interleukin‐1 (IL‐1) is a key mediator of inflammation in cerebral ischemia, but its precise mechanisms of action remain elusive. Temperature is critical to outcome in brain injury and given the importance of IL‐1 in pyrogenesis this has clear mechanistic im