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Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

โœ Scribed by Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.


Book ID
111985261
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
85 KB
Volume
46
Category
Article
ISSN
0022-2623

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โœ John E. Kerrigan; Daniel S. Pilch; Alexander L. Ruchelman; Nai Zhou; Angela Liu; ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 318 KB

In this paper, we present our results from a docking study of the title compounds with the DNA/topoisomerase I complex based on the recently published X-ray crystal structure of the topotecan/DNA/topoisomerase I ternary cleavable complex (Staker, B.L., et al. PNAS 2002, 99, 15387) using the Autodock