✦ LIBER ✦

Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones

✍ Scribed by Lisa Sharma; Yuan-Chin Tsai; Angela A. Liu; Leroy F. Liu; Edmond J. LaVoie

Book ID: 108116208
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 261 KB
Volume: 44
Category: Article
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2008.09.048

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

5H-8,9-Dimethoxy-5-(2-N,N-dimethylaminoe

5H-8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h]naphthyridin-6-ones and related compounds as TOP1-Targeting agents: influence of structure on the ternary cleavable complex formation

✍ John E. Kerrigan; Daniel S. Pilch; Alexander L. Ruchelman; Nai Zhou; Angela Liu; 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 318 KB

In this paper, we present our results from a docking study of the title compounds with the DNA/topoisomerase I complex based on the recently published X-ray crystal structure of the topotecan/DNA/topoisomerase I ternary cleavable complex (Staker, B.L., et al. PNAS 2002, 99, 15387) using the Autodock

Nitro and Amino Substitution in the D-Ri

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

✍ Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 85 KB

Dimethoxybenzo[i]phenanthridine-12-carbo

Dimethoxybenzo[i]phenanthridine-12-carboxylic Acid Derivatives and 6H-Dibenzo[c,h][2,6]naphthyridin-5-ones with Potent Topoisomerase I-Targeting Activity and Cytotoxicity.

✍ Alexander L. Ruchelman; Shejin Zhu; Nai Zhou; Angela Liu; Leroy F. Liu; Edmond J 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Structures of 5-dimethylamino-1-[N-(2,6-

Structures of 5-dimethylamino-1-[N-(2,6-dimethylphenyl)benzimidoyl]tetrazole, C18H20N6, and 7,9-dimethyl-5-dimethylamino-2-phenyl-3H-1,3,4-benzotriazepine, C18H20N4

✍ Lindley, P. F. ;Boyd, G. V. ;Nicolaou, G. A. 📂 Article 📅 1990 🏛 International Union of Crystallography 🌐 English ⚖ 544 KB

Structure of 6-amino-1,3-dimethyl-5-[5-(

Structure of 6-amino-1,3-dimethyl-5-[5-(dimethylamino)-1,2,3,4-tetrazol-1-yl]uracil hemihydrate: C9H14N8O2.1/2H2O

✍ Cousson, A. ;Proust, J. ;Bachet, B. ;Kokel, B. ;Hubert-Habart, M. 📂 Article 📅 1992 🏛 International Union of Crystallography 🌐 English ⚖ 305 KB

VIBRATIONAL SPECTROSCOPIC INVESTIGATIONS

VIBRATIONAL SPECTROSCOPIC INVESTIGATIONS OF 4-ALKYL 4′-CYANO BIPHENYLS [C n H 2n+1 -C 6 H 5 -C 6 H 5 -CN, n = 9, 10 and 11]

✍ Murty, K. V. G. K.; Manisekharan, T.; Srinivasan, T. K. K. 📂 Article 📅 2004 🏛 Taylor and Francis Group 🌐 English ⚖ 349 KB