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Nitriles in Organic Synthesis A Route to Polyfunctionally Substituted Azabiaryls

✍ Scribed by Nadia S. Ibrahim; Mona H. Mohamed; Mohamed H. Elnagdi

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 198 KB
Volume: 321
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19883210919

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✦ Synopsis

In previous work we have shown that the reaction of trichloroacetonitrile with bifunctional nitriles leads to arninoheterocycles having a trichloromethyl substituentl). The trichloromethyl function in these heteroaromatic amines can be readily replaced by nucleophilic reagents'). Recent interest in utility of this synthetic approhch for preparation of aromatic aminoheter~cycles*-~) as well as reported abnormal reactivity of the trichloromethyl function in n-deficient heterocycles5) prompt us to report our further results in this area. This work was undertaken in connection with a biological chemistry project in our laboratories when samples of different derivatives of azabiaryls were required.

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