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Dimethylformamide dimethyl acetal in heterocyclic synthesis: Synthesis of polyfunctionally substituted pyridine derivatives as precursors to bicycles and polycycles

✍ Scribed by Fathi A. Abu-Shanab; A. M. Hessen; S. A. S. Mousa

Publisher: Journal of Heterocyclic Chemistry
Year: 2007
Tongue: English
Weight: 308 KB
Volume: 44
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570440406

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✦ Synopsis

Abstract

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Polysubstituted pyridines 11a,c and 12 were prepared by the reaction of benzoylacetone with dimethylformamide dimethyl acetal followed by treatment with cyanothioacetamide 9a, cyanoacetamide 9b and the anion of malononitrile dimmer 9c in dry DMF. When the reaction was carried out in ethanol as a solvent and piperidine as a base afforded 14a,b. Thienopyridines 16a,b were prepared by the reaction of pyridinethiones 11a and 14a with 2‐chloro‐N‐p‐tolyl‐acetamide (15). Further reaction of thienopyridines 16a,b with either DMFDMA or nitrous acid to gave 17a,b and 18a,b respectively. The reaction of pyridine derivative 11c with hydrazine and phenylhydrazine afforded the tricyclic compounds 19a,b.

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