✦ LIBER ✦

Nitrilase-Catalyzed Enantioselective Synthesis of Pyrrolidine- and Piperidinecarboxylic Acids

✍ Scribed by Margit Winkler; Dorith Meischler; Norbert Klempier

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 93 KB
Volume: 349
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200700040

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The enantioselective synthesis of the non‐proteinogenic amino acids β‐proline and nipecotic acids from their readily available nitriles is achieved in high enantiomeric excess by commercially available nitrilases. The presented procedure comprises not more than 4 steps, thus considerably reducing the multiple steps generally required. Amide formation is also observed for specific heterocyclic nitriles.

📜 SIMILAR VOLUMES

Synthesis of 2-Piperidinecarboxylic Acid

Synthesis of 2-Piperidinecarboxylic Acid and Its Derivatives.

✍ A. A. Bazurin; T. A. Obukhova; S. V. Krasnikov; A. F. Betnev; O. N. Ovsyanikov 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

Modern Biocatalysis || Nitrilase- and Ni

Modern Biocatalysis || Nitrilase- and Nitrile Hydratase-Catalyzed Enantioselective Preparation of Non-Proteinogenic Amino Acids

✍ Fessner, Wolf-Dieter; Anthonsen, Thorleif 📂 Article 📅 2008 🏛 Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German ⚖ 225 KB 👁 1 views

This reference covers the wide and rapidly growing field of biocatalysis. It combines complementary expertise from such areas as microbiology, enzymology, molecular biology, structural biology and organic chemistry, this highlighting the interdisciplinary nature of the subject. With its special focu

ChemInform Abstract: Nitrilase and Nitri

ChemInform Abstract: Nitrilase and Nitrile Hydratase Catalyzed Enantioselective Preparation of Non-Proteinogenic Amino Acids

✍ Norbert Klempier; Margit Winkler 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 11 KB

Modern Biocatalysis || Nitrilases in the

Modern Biocatalysis || Nitrilases in the Enantioselective Synthesis ofÎ±-Hydroxycarboxylic Acids

✍ Fessner, Wolf-Dieter; Anthonsen, Thorleif 📂 Article 📅 2008 🏛 Wiley-VCH Verlag GmbH & Co. KGaA 🌐 German ⚖ 248 KB 👁 1 views

ChemInform Abstract: Nitrilases in the E

ChemInform Abstract: Nitrilases in the Enantioselective Synthesis of α-Hydroxycarboxylic Acids

✍ Fred van Rantwijk; Cesar Mateo; Andrzej Chmura; Bruno C. M. Fernandes; Roger A. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 17 KB

Broensted Acid-Catalyzed Intramolecular

Broensted Acid-Catalyzed Intramolecular Hydroamination of Protected Alkenylamines. Synthesis of Pyrrolidines and Piperidines.

✍ Bjoern Schlummer; John F. Hartwig 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB