Nitric oxide synthase expression is downregulated in basal cell carcinoma of the head and neck
β Scribed by P.A. Brennan; T. Umar; J. Bowden; A. Hobkirk; A.V. Spedding; B. Conroy; G. Zaki; D.W. Macpherson
- Book ID
- 117834668
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 136 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0266-4356
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## Abstract ## Background Extracapsular nodal spread is a major prognostic indicator in head and neck cancer. Nitric oxide (NO), primarily produced by the enzyme inducible NO synthase (iNOS), has a large number of actions in cancer biology, but no studies have investigated its possible role in ext
Combinations of cytokines andor phorbol ester induce expression of Type I1 nitric oxide synthase (NOS) mRNA in astrocyte cultures via protein kinase mediated pathways (Simmons and Murphy: GLIA 11:227,1994; Feinstein et al.: J Neurochem 62:811, 1994). Agonists that activate receptors linked to protei