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Nitric oxide-releasing sulindac inhibits pancreatic cancer cell growth and induces their apoptosis

✍ Scribed by Qiao, Liang; Rigas, Basil; Knudson, C. Michael


Book ID
124110023
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
170 KB
Volume
120
Category
Article
ISSN
0016-5085

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Pancreatic cancer cells are usually resistant to apoptosis induced by cytotoxic drugs, by activation of surface receptors such as Fas and TNF receptor or by serum or growth factor withdrawal. Actinomycin D (actD) is an inhibitor of RNA synthesis and acts as a potent inducer of apoptosis in several c