Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells
β Scribed by Stephan Immenschuh; Melly Tan; Giuliano Ramadori
- Book ID
- 118568887
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 908 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0168-8278
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π SIMILAR VOLUMES
Altered expression and activity of immunomodulatory cytokines plays a major role in the pathogenesis of alcoholic liver disease. Chronic ethanol feeding increases the sensitivity of Kupffer cells, the resident hepatic macrophage, to lipopolysaccharide (LPS), leading to increased tumor necrosis facto
Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe