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Constitutive and lipopolysaccharide regulated gene expression of the antioxidant heme oxygenase-1 in kupffer cells of rat liver

โœ Scribed by S. Immenschuh; M. Tan; T. Kietzmann; G. Ramadori


Book ID
118568289
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
155 KB
Volume
28
Category
Article
ISSN
0168-8278

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Increased heme oxygenase-1 gene expressi
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Heme oxygenase (HO) catalyzes the conversion of heme into biliverdin, iron, and carbon monoxide (CO). Two isoforms of HO have been identified: the inducible HO-1 and the constitutive HO-2. CO, like nitric oxide, is an endogenous vasodilator that could contribute to modulation of systemic and local v