Nitric oxide mediates cytokine-induced enhancement of Ca2+-dependent Glu release from astrocytes
✍ Scribed by Ida, Tomoaki; Nakamura, Yoichi; Kozaki, Shunji; Ihara, Hideshi
- Book ID
- 122460486
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 92 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0168-0102
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## Abstract Nitric oxide (NO; 1 μM) or an NO donor (500 μM diethylenetriamine‐nitric oxide, DETA‐NONOate) caused rapid glutamate and ATP release from cultured rat cortical astrocytes. NO‐induced glutamate release was prevented by calcium chelators (EGTA or BAPTA‐AM) and an inhibitor of vesicular ex
## Abstract Since NO production by NOS‐2 made by astrocytes activated by proinflammatory cytokines contributes to the killing of neurons in variously damaged human brains, knowing the mechanisms responsible for NOS‐2 expression should contribute to developing effective therapeutics. The expression