Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide
✍ Scribed by Tomoaki Ida; Masayuki Hara; Yoichi Nakamura; Shunji Kozaki; Shigeru Tsunoda; Hideshi Ihara
- Book ID
- 116770103
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 293 KB
- Volume
- 432
- Category
- Article
- ISSN
- 0304-3940
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📜 SIMILAR VOLUMES
## Abstract Nitric oxide (NO; 1 μM) or an NO donor (500 μM diethylenetriamine‐nitric oxide, DETA‐NONOate) caused rapid glutamate and ATP release from cultured rat cortical astrocytes. NO‐induced glutamate release was prevented by calcium chelators (EGTA or BAPTA‐AM) and an inhibitor of vesicular ex
## Abstract Hydroxylamine (0.01–30 mM), a nitric oxide (NO) generator, produced a concentration‐dependent release of [^3^H]dopamine ([^3^H]DA) from rat striatal slices. Hemoglobin (10 μM), a NO scavenger, reduced basal [^3^H]DA release and blocked hydroxylamine (100 μM)‐stimulated [^3^H]DA efflux.
Combinations of cytokines andor phorbol ester induce expression of Type I1 nitric oxide synthase (NOS) mRNA in astrocyte cultures via protein kinase mediated pathways (Simmons and Murphy: GLIA 11:227,1994; Feinstein et al.: J Neurochem 62:811, 1994). Agonists that activate receptors linked to protei