## Abstract The mitochondriaโmediated apoptotic pathway is regulated by members of the Bclโ2 family. Epidermal growth factor (EGF) induces Bad phosphorylation at Ser~112~ via mitogenโactivated protein kinase (MAPK), impairing its binding to Bclโ2 and BclโxL and interfering with their antiโapoptotic
Nitric Oxide Induces Osteoblast Apoptosis through a Mitochondria-Dependent Pathway
โ Scribed by WEI-PIN HO; TA-LIANG CHEN; WEN-TA CHIU; YU-TING TAI; RUEI-MING CHEN
- Book ID
- 111479199
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 628 KB
- Volume
- 1042
- Category
- Article
- ISSN
- 0890-6564
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๐ SIMILAR VOLUMES
## Abstract Nitric oxide (NO) contributes to the regulation of osteoblast activities. In this study, we evaluated the protective effects of NO pretreatment on oxidative stressโinduced osteoblast apoptosis and its possible mechanism using neonatal rat calvarial osteoblasts as the experimental model.
It is NO that mediates the inhibitory effect of IFN-gamma, MIP-1alpha and TNFalpha on hematopoiesis. However, the mechanism for NO effect on the hematopoietic system is likely to not clear. In the current work, we demonstrates that NO can directly suppress the colony formation of granulocyte/macroph