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Nitric oxide associated hypotensive and vasodilating effects of adrenomedullin in rats

โœ Scribed by Matsunaga, K.; Iwasaki, T.; Yonetani, Y.; Kitamura, K.; Eto, T.; Kangawa, K.; Matsuo, H.

Book ID
123368104
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
104 KB
Volume
1
Category
Article
ISSN
0928-4680

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Nitric oxide-dependent hypotensive effec
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โœ Kazuki Matsunaga; Takanori Iwasaki; Yukio Yonetani; Kazuo Kitamura; Tanenao Eto; ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 484 KB ๐Ÿ‘ 2 views

The association of nitric oxide (NO) with the hypotensive effects of adrenomedullin (AM) was investigated in anesthetized rats. Spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) were used at 11-13 weeks of age. Blood pressure and heart rate were measured from the femoral

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Nitric oxide-associated relaxing effects of adrenomedullin in rat aorta
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The relaxing effect of adrenomedullin (AM) and that associated with nitric oxide (NO) were investigated in rat isolated aorta. The relaxing effect produced by AM was almost completely inhibited by the removal of endothelium and by treatment with the NOS inhibitor fl-nitro-L-arginine methyester (L-NA