Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism

HLA Class ii sequence polymorphisms and

HLA Class ii sequence polymorphisms and susceptibility to rheumatoid arthritis in greeks. the hla–drβ shared-epitope hypothesis accounts for the disease in only a minority of greek patients

✍ Kyriaki A. Boki; Gabriel S. Panayi; Robert W. Vaughan; Alexandros A. Drosos; Har 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed