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Nilotinib in Imatinib-Resistant CML and Philadelphia Chromosome–Positive ALL

✍ Scribed by Kantarjian, Hagop; Giles, Francis; Wunderle, Lydia; Bhalla, Kapil; O'Brien, Susan; Wassmann, Barbara; Tanaka, Chiaki; Manley, Paul; Rae, Patricia; Mietlowski, William


Book ID
111980273
Publisher
Massachusetts Medical Society
Year
2006
Tongue
English
Weight
186 KB
Volume
354
Category
Article
ISSN
0096-6762

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## Abstract In patients with chronic myeloid leukemia (CML), resistance against imatinib is associated with mutations in the kinase domain (KD) of the __BCR‐ABL1__ fusion gene and/or with additional chromosomal abnormalities (ACAs) secondary to the Philadelphia chromosome. To evaluate associations