The dorsal hippocampus (DH) is critically involved in the acquisition and expression of trace and contextual fear conditioning. NMDA/glutamate receptor-mediated transmission is thought to be one mechanism mediating the plastic changes that support long-term memories in the DH. However, their precise
Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning
โ Scribed by Justin W. Kenney; Jonathan D. Raybuck; Thomas J. Gould
- Book ID
- 112098211
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 464 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1050-9631
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## Abstract Trace conditioning relies on the maintained representation of a stimulus across a trace interval, and may involve a persistent trace of the conditioned stimulus (CS) and/or a contribution of contextual conditioning. The role of hippocampal structures in these two types of conditioning w
Recent data demonstrate weaker g-aminobutyric acid (GABA)-ergic inhibition in ventral (VH) compared with dorsal (DH) hippocampus. Therefore, we examined possible differences regarding the GABA A receptors between VH and DH as follows: 1) the expression of the GABA A receptor subunits (a1/2/4/5, b1/2