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Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

✍ Scribed by Schro¨der, Hannsjo¨rg; Giacobini, Ezio; Struble, Robert G.; Zilles, Karl; Maelicke, Alfred

Book ID
122641563
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
509 KB
Volume
12
Category
Article
ISSN
0197-4580

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Nicotinic acetylcholine receptor subtype
Nicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease
✍ K. Sugaya; E. Giacobini; V. A. Chiappinelli 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 993 KB

## Abstract Molecular genetic and pharmacological studies have suggested that several subtypes of nicotinic acetylcholine receptors exist in the mammalian and avian brain. Combining ^3^H‐(−)‐nicotine, ^125^ I‐α‐bungarotoxin, and ^125^I‐κ‐bungarotoxin as ligands, we report here the first evidence fo