The antidyskinetic potential of the glutamate NMDA receptor channel blocker amantadine was evaluated in four levodopa-primed parkinsonian monkeys using two different regimens (1.25 or 2.5 mg/kg administered subcutaneously twice daily for 3-6 days). When administered with a relatively low dose of lev
Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys
✍ Scribed by Maryka Quik; Heather Cox; Neeraja Parameswaran; Kathryn O'Leary; J. William Langston; Donato Di Monte
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 333 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0364-5134
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## Abstract ## Objective The objective of the present study was to investigate the effect of docosahexaenoic acid (DHA), a polyunsaturated fatty acid (omega‐3), on levodopa‐induced dyskinesias (LIDs) in parkinsonian 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)–treated monkeys. ## Methods
## Abstract Overactive AMPA receptor‐mediated transmission may be involved in the pathogenesis of levodopa‐induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor‐mediated transmission. In this study, the potential antidyskinetic actio