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Nicotine decreases agrin signaling and acetylcholine receptor clustering in C2C12 myotube culture

✍ Scribed by Ferayorni, Angelique J. ;Gunville, Cameron F. ;Grow, Wade A.


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
246 KB
Volume
60
Category
Article
ISSN
0022-3034

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## Abstract Protein kinase C (PKC) activity has been implicated in nicotinic acetylcholine receptor (nAChR) cluster disruption but the specific PKC isoforms involved have not been identified. We first tested whether phorbol esters, which activate PKCs, regulate agrin‐induced nAChR clustering in C~2