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Nicastrin Overexpression in Transgenic Mice Induces Aberrant Behavior and APP Processing

✍ Scribed by Jun Seo Goo, Yong Bin Kim, Sun Bo Shim, Seung Wan Jee, Su Hae Lee…

Book ID
120899999
Publisher
Springer
Year
2013
Tongue
English
Weight
908 KB
Volume
48
Category
Article
ISSN
0893-7648

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Induced expression of neurotrophins in transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine
✍ M. Reeben; J. Arbatova; J. Palgi; R. Miettinen; M. Halmekytö; L. Alhonen; J. Jän 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 749 KB

Transgenic mice overexpressing ornithine decarboxylase (ODC) were recently generated (Halmekyto et al.: Biochem Biophys Res Commun 180:262-267, 1991). The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. As elevated polyamine levels in the br