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Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice

✍ Scribed by Jaehoon Lee; Hye Jin Kim; Jung Ah Moon; Young Hoon Sung; In-Jeoung Baek; Jae-il Roh; Na Young Ha; Seung-Yeon Kim; Young Yil Bahk; Jong Eun Lee; Tae Hyun Yoo; Han-Woong Lee


Book ID
108789927
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
561 KB
Volume
92
Category
Article
ISSN
0959-9673

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Transgenic mice overexpressing ornithine decarboxylase (ODC) were recently generated (Halmekyto et al.: Biochem Biophys Res Commun 180:262-267, 1991). The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. As elevated polyamine levels in the br