The trifluoroacetic acid labile pentamethylchromanylsulphonyl protecting group for the guanidino group of arginine has been used in conjunction with the base-labile Fmoc Ne protecting group for the synthesis of arginine-containing peptides.
NG-2,2,5,7,8-pentamethylchroman-6-sulphonyl-L-arginine: A new acid labile derivative for peptide synthesis
β Scribed by R. Ramage; J. Green
- Book ID
- 104227587
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 242 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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A study aimed at developing an enantioselective synthesis of the title compound 23, a 2-monodeoxy analogue of the naturally occurring ()-2-keto-3-deoxy-d-glycero-d-galacto-2-nononic acid (KDN), is reported. From d-mannose as starting material, the chiral 1,3-diene 10, activated by a silyloxy substit
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