NF2: The wizardry of merlin

✍ Scribed by Guang-Hui Xiao; Jonathan Chernoff; Joseph R. Testa

• Book ID: 102219166
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 107 KB
• Volume: 38
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.10282

✦ Synopsis

Abstract

Neurofibromatosis type II (NF2) is an autosomal dominant cancer syndrome characterized by the formation of tumors of the nervous system, particularly schwannomas and meningiomas. The NF2 gene is also implicated in the development of sporadic schwannomas and meningiomas, as well as tumor types seemingly unrelated to the NF2 disorder, such as malignant mesotheliomas. Inactivation of NF2 occurs by a “two‐hit” mechanism, as proposed by Al Knudson, and the NF2 gene behaves as a classical tumor suppressor gene. The NF2 gene product, merlin, exhibits homology with the ezrin–radixin–moesin family of membrane–cytoskeleton‐linking proteins. During the past several years, there has been intensive investigation aimed at elucidating the mechanisms underlying merlin's functions. In this review, we summarize the involvement of NF2 inactivation in tumorigenesis. We also discuss observations implicating merlin in cell motility and cell proliferation, with a focus on recent findings linking merlin to Rac signaling. © 2003 Wiley‐Liss, Inc.