NF1 Deletions in S-100 Protein-Positive and Negative Cells of Sporadic and Neurofibromatosis 1 (NF1)-Associated Plexiform Neurofibromas and Malignant Peripheral Nerve Sheath Tumors
β Scribed by Arie Perry; Kevin A. Roth; Ruma Banerjee; Christine E. Fuller; David H. Gutmann
- Book ID
- 117021182
- Publisher
- American Society for Investigative Pathology
- Year
- 2001
- Tongue
- English
- Weight
- 716 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0002-9440
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Peripheral nerve sheath tumors arise either sporadically or in association with neurofibromatosis type 1 (von Recklinghausen's neurofibromatosis, NF1) or type 2. In this study, comprehensive screening for relative chromosome copy number changes was performed on 10 benign and 19 malignant peripheral
Neurofibromatosis type-1 (NF1) is associated with the growth of benign and malignant tumors. Approximately 15% of NF1 patients develop malignant peripheral nerve sheath tumors (MPNSTs), underlining the need to identify specific diagnostic/prognostic biomarkers associated with MPNST development. The