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NF-κB is Involved in the Induction of the Rat Hepatic α1-Acid Glycoprotein Gene by Phenobarbital

✍ Scribed by Najet Mejdoubi; Cécile Henriques; Elizabeth Bui; Dominique Porquet

Book ID: 115583163
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 165 KB
Volume: 254
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1998.9903

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Nuclear factor-jB is a transcription factor that is activated in many different cell types by pathologic stimuli, such as reactive oxygen intermediates. One class of hepatocarcinogens, the peroxisome proliferators, may produce reactive oxygen intermediates, and one potent peroxisome proliferator, ci