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Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes

✍ Scribed by Abdelhamid Liacini; Judith Sylvester; Wen Qing Li; Wensheng Huang; Faramaze Dehnade; Mushtaq Ahmad; Muhammad Zafarullah

Book ID
117099871
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
507 KB
Volume
288
Category
Article
ISSN
0014-4827

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## Abstract Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM) synthesis. Tissue inhibitor of metalloproteinases‐3 (TIMP‐3) is located in ECM and is the major inhibitor of matrix metalloproteinases (MMPs) and aggrecanase,