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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

✍ Scribed by Nidai Ozes, Osman; Mayo, Lindsey D.; Gustin, Jason A.; Pfeffer, Susan R.; Pfeffer, Lawrence M.; Donner, David B.


Book ID
109809059
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
240 KB
Volume
401
Category
Article
ISSN
0028-0836

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## Abstract Tumor necrosis factor (TNF) is one of the most potent activators of nuclear transcription factor NF‐κB, c‐Jun N‐terminal protein kinase (JNK), and apoptosis in a wide variety of cells. The biological effects of TNF are mediated through sequential interactions of various cytoplasmic prot