Cellular resistance to vincristine suppresses NF-κB activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis factor

Lack of requirement of STAT1 for activat

Lack of requirement of STAT1 for activation of nuclear factor-κB, c-Jun NH2-terminal protein kinase, and apoptosis by tumor necrosis factor-α

✍ Asok Mukhopadhyay; Shishir Shishodia; Xin-Yuan Fu; Bharat B. Aggarwal 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 377 KB

## Abstract Tumor necrosis factor (TNF) is one of the most potent activators of nuclear transcription factor NF‐κB, c‐Jun N‐terminal protein kinase (JNK), and apoptosis in a wide variety of cells. The biological effects of TNF are mediated through sequential interactions of various cytoplasmic prot