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NF-κB activation by protein kinase C isoforms and B-cell function

✍ Scribed by Moscat, Jorge; Diaz-Meco, María T.; Rennert, Paul


Book ID
110033512
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
185 KB
Volume
4
Category
Article
ISSN
1469-221X

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Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCb is indispensable for B-cell antigen receptor (BCR)-induced NF-kB activation and B-cell survival. Recent evidence indicates that PKCb