Protein kinase C family functions in B-cell activation

✍ Scribed by Beichu Guo; Thomas T Su; David J Rawlings

• Publisher: Elsevier Science
• Year: 2004
• Tongue: English
• Weight: 295 KB
• Volume: 16
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2004.03.012

✦ Synopsis

Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCb is indispensable for B-cell antigen receptor (BCR)-induced NF-kB activation and B-cell survival. Recent evidence indicates that PKCb might regulate inhibitor of kB kinase (IKK) and NF-kB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCd is specifically required to maintain the tolerance of self-reactive B cells.