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Newly identified genetic risk variants for celiac disease related to the immune response

✍ Scribed by Hunt, Karen A; Zhernakova, Alexandra; Turner, Graham; Heap, Graham A R; Franke, Lude; Bruinenberg, Marcel; Romanos, Jihane; Dinesen, Lotte C; Ryan, Anthony W; Panesar, Davinder

Book ID
109914158
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
469 KB
Volume
40
Category
Article
ISSN
1061-4036

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We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P ΒΌ 2.0 Γ‚ 10 -7 ) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further