✦ LIBER ✦

New uses for endothelial cell culture

✍ Scribed by Una S. Ryan

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 539 KB
Volume: 1
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950010306

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Endothelial cells in culture have, in the past, been a valuable but capricious tool to test hypotheses on the role of components of the blood vessel wall in such functions as blood pressure homeostasis, hemostasis, permeability, transport of macromolecules and the processing of circulating biologically active substances. Now techniques are becoming available for raising long‐term, large‐scale cultures that can be maintained reproducibly and without loss of phenotypic characteristics. The outlook for establishing endothelial cell factories invites speculation on some far‐reaching possibilities, such as endothelial cell banks that could be used for seeding autogenous cells on vascular prostheses, artificial kidney tubing, heart valves, or corneas, or for virus production, or for synthesis by endothelial cells of products at present beyond the reach of bacterial cells.

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