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New Trends in Synthesis of Pyrazole Nucleosides as New Antimetabolites

✍ Scribed by Elgemeie, Galal H.; Zaghary, Wafaa A.; Amin, Kamelia M.; Nasr, Tamer M.


Book ID
120063204
Publisher
Taylor and Francis Group
Year
2005
Tongue
English
Weight
465 KB
Volume
24
Category
Article
ISSN
0732-8311

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A new route to the synthesis of pyrazole
✍ Carlo F Morelli; Manferdini Monica; Augusto C Veronese πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 730 KB

A new route to the synthesis of pyrazole and pyrimidine C-nucleosides, which involves as the key step a metal promoted reaction of ~-D-ribofuranosyl ketoesters with alkyl cyanoformates is described. 2,3,5-Tri-O-benzoyl-~-D-ribofuranosyl cyanide I reacts with ct-bromoesters, in the presence of zinc d