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New Trends in Synthesis of Pyrazole Nucleosides as New Antimetabolites

✍ Scribed by Galal H. Elgemeie; Wafaa A. Zaghary; Kamelia M. Amin; Tamer M. Nasr


Book ID
101984548
Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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A new route to the synthesis of pyrazole
✍ Carlo F Morelli; Manferdini Monica; Augusto C Veronese πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 730 KB

A new route to the synthesis of pyrazole and pyrimidine C-nucleosides, which involves as the key step a metal promoted reaction of ~-D-ribofuranosyl ketoesters with alkyl cyanoformates is described. 2,3,5-Tri-O-benzoyl-~-D-ribofuranosyl cyanide I reacts with ct-bromoesters, in the presence of zinc d