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New trends in macromolecular X-ray crystallography

✍ Scribed by Jean-Pierre Wery; Richard W Schevitz

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 605 KB
Volume: 1
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(97)80075-0

No coin nor oath required. For personal study only.

✦ Synopsis

Advances in experimental and computational techniques have reaffirmed the role of protein X-ray crystallography as one of the primary providers of structural information both to enhance our fundamental understanding of biological systems and also to assist the design and optimization of important therapeutics. Today, the most important challenge facing macromolecular X-ray crystallography is the need to grow suitable crystals of a given protein. Once this has been accomplished, most often the question is not whether the structure will be solved but rather how fast this will be done. A dramatic example of this is the crystal structure of cytochrome c oxidase. The search for crystallization conditions took about 15 years and then the structure was solved in about one year.

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