New topoisomerases inhibitors: Synthesis of rutaecarpine derivatives and their inhibitory activity against topoisomerases
โ Scribed by Kim, Seung Ill; Lee, Seung Ho; Lee, Eung-Seok; Lee, Chong-Soon; Jahng, Yurngdong
- Book ID
- 113100939
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 784 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0253-6269
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In order to find potential anticancer drug candidate targeting topoisomerases enzyme, we have designed and synthesized oxiranylmethoxy-and thiiranylmethoxy-retrochalcone derivatives and evaluated their pharmacological activity including topoisomerases inhibitory and cytotoxic activity. Of the compou