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New synthetic strategy for the synthesis of 24-epibrassinolide

✍ Scribed by Carme Brosa; Rita Puig; Xavier Comas; Cristina Fernández


Book ID
117213763
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
364 KB
Volume
61
Category
Article
ISSN
0039-128X

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A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (±)-biotin 1.