A new synthetic route to highly enantioe
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Eric Deniau; Dieter Enders; Axel Couture; Pierre Grandclaudon
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Article
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2003
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Elsevier Science
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English
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A concise and efficient synthesis of highly enantioenriched 3-alkyl and 3-aryl-2,3-dihydro-1H-isoindolinones is reported. The key step relies on the diastereoselective reduction of the N-acylhydrazonium salts generated by acidic treatment of hemiaminal precursors bearing the (S)-2-methoxymethylpyrro