New synthesis of β-amino acids by nucleophilic addition of enolate anions to N-methoxycarbonylimines generated from α-methoxy carbamates1

✍ Scribed by Tatsuya Shono*; Naoki Kise; Fumio Sanda; Satoru Ohi; Kenji Tsubata

• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 236 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)80062-3

✦ Synopsis

Sumnary

The nucleophillc addltlon of enolate anions of alkyl acetates to N-methoxcarbonylimlnes generated from a-methoxy carbamates gave 8-amino acid derivatives (2 J and enantloselectlve synthesis (72-90%ee) of 2 was achieved by using choral 2-methyloxazolines Instead of acetates.