Diastereoselectivity in the addition of enolate anions to N-methoxycarbonylimines generated in situ from α-methoxy carbamates

New synthesis of β-amino acids by nucleo

New synthesis of β-amino acids by nucleophilic addition of enolate anions to N-methoxycarbonylimines generated from α-methoxy carbamates1

✍ Tatsuya Shono*; Naoki Kise; Fumio Sanda; Satoru Ohi; Kenji Tsubata 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 236 KB

## Sumnary The nucleophillc addltlon of enolate anions of alkyl acetates to N-methoxcarbonylimlnes generated from a-methoxy carbamates gave 8-amino acid derivatives (2 J and enantloselectlve synthesis (72-90%ee) of 2 was achieved by using choral 2-methyloxazolines Instead of acetates.